We develop evolutionary protein design methods to elucidate principles of biological design and generate novel and useful enzymes and organisms.

Recent Highlights

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Prospective graduate students should apply through the appropriate PhD option (ChEBEBMBChemBio or other).

Congratulations to Stephan Hammer, Grezgorz Kubik, Ella Watson, Shan Huang, and Hannah Minges for their paper on beating catalysts at the oxidation game. Congratulations to Anders Knight, who won the best poster award at the ECI Enzyme Engineering Conference in Toulouse, France.

Congratulations to David Romney, Javier Murciano-Calles, and Jöri Wehrmüller, whose paper on synthesizing tryptophan analogues has been selected by the Editorial Board of Synfacts for its important insights as “Synfact of the Month”.

Congratulations to Chris Prier and Kelly Zhang, whose paper on asymmetric C-H amination has been selected by the Editorial Board of Synfacts for its important insights as “Synfact of the Month”.

Frances Arnold is the recipient of the Society of Women Engineers’ 2017 Achievement award.

Congratulations to Kevin Yang (grad), one of the three recipients to receive the first ever CCE Teaching Assistantship Award, presented to the divison’s most exceptional teaching assistants.

Congratulations to Kari Hernandez (grad), the 2016 winner of the Constantin G. Economou Memorial Prize for outstanding candidacy research in Chemical Engineering.

Congratulations to Andy Buller, who will join U. Wisconsin Chemistry.

“Using Synthetic Biology to Engineer Membrane Proteins.”Twist Bioscience Blog (March 6, 2017)

Frances Arnold is the recipient of the 2017 Raymond and Beverly Sackler Prize in Convergence Research

“Engineering Green Biocatalysts for Chemical Reactions Not Known in Biology,” K.E. Hernandez, ACS Green Chemistry: The Nexus Blog (2017)

C&EN Top Research of 2016: First C-Si bond forming enzyme

First carbon-silicon bond-forming enzyme! Kan et al., Science (2016). doi: 10.1126/science.aah6219.

Huge congratulations to Jenny Kan (postdoc), Rusty Lewis (grad), and Kai Chen (grad) on winning the 2016 $10,000 grand prize Dow-Sustainability Innovation Student Challenge Award (SISCA).

“Highly Stereoselective Biocatalytic Synthesis of Key Cyclopropane Intermediate to Ticagrelor,” Hernandez et al.,ACS Catalysis (2016). doi: 10.1021/acscatal.6b02550

“A General Tool for Engineering the NAD/NADP Cofactor Preference of Oxidoreductases,” Cahn et al., ACS Synthetic Biology (2016). doi: 10.1021/acssynbio.6b00188

Congratulations to Andrew Buller on his new route to beta-methyl Trps, highlighted in C&ENews

Frances Arnold wins 2016 Millennium Technology Prize

Congratulations to Jackson Cahn (grad) on winning a 2016 Herbert Newby McCoy Award, given to the most outstanding graduate students in the Division of Chemistry and Chemical Engineering at Caltech

Congratulations to Stephan Hammer (postdoc) on winning a 2016 Deutsche Forschungsgemeinschaft (DFG) postdoctoral fellowship

Congratulations to Andy Buller, Austin Rice and David Romney (postdocs) on each winning a 2015/2016 NIH Ruth L. Kirschstein NRSA postdoctoral fellowship

Congratulations to Kevin Yang and Ruijie Kelly Zhang (grads), both appointed to the inaugural cohort of the Biotechnology Leadership Training Grant Program at Caltech (2015)

Congratulations to Claire Bedbrook (grad) on winning a 2014 NIH Ruth L. Kirschstein NRSA predoctoral fellowship